African
Journals Online
African Journal of Clinical and Experimental Microbiology
Volume 4 Number 1 January, 2003
THE EFFECT OF SCHISTOSOMA MANSONI
CERCARIA INFECTION AND TREATMENT WITH NIRIDAZOLE ON TESTICULAR
HISTOLOGY OF THE MICE.
BY DAFUR, SYLVNUS JOSIAH* AND LAR, PATRICIA MANKO**
*Department of Anatomy, Faculty of Medical Sciences, University
of Jos, PMB 2084, Jos, Nigeria. **Department of Microbiology,
Faculty of Natural Sciences, University of Jos, PMB 2084, Jos,
Nigeria. Correspondent Address: DR. S.J. DAFUR, Department
of Anatomy, Faculty of Medical Sciences, University of Jos, PMB
2084, Jos Nigeria.
E-mail: [email protected], [email protected]
The testicular histology of mice infected with Schistosoma
mansoni (S.mansoni) cercaria and treated with
Niridazole was examined. The results reveal that infection of
mice with Schistosoma mansoni cercariae resulted in
distortion of the testicular cyto-architecture including
disruption of spermatogenesis as shown by the absence of
spermatozoa in the lumen of the sominiferous tubule and
distruction of the inter-tubular connective tissue of the
infected mice. These changes were reversed to normalcy following
two-course treatment of the infected mice with Niridazole after
five weeks.
INVESTIGATION OF THE EFFICACY OF TWO RAPID ASSESSMENT
TECHNIQUES (OPTIMAL 1 AND SD-BIOLINE) FOR THE DIAGNOSIS OF
MALARIA IN RURAL AREAS OF NIGERIA
P.U. AGOMO, V.N. ASIANYA, S.K. AKINDELE, C.O. AGOMO, M.O.
AKINYELE, T.A. ADEWOLE, U.T. IGBASI, RC ANYANWU and K.N. EGBUNA.
Division of Biochemistry and Nutrition, Nigerian Institute of
Medical research, P.M.B. 2013, Yaba, Lagos.
Correspondence: Dr. P.U. AGOMO, Biochemistry Division, NIMR,
PMB 2013, Yaba, Lagos
We had previously studied the efficacy of three new
techniques-Para Sight F, (PSF), Immunochromatographic Test (ICT)
and Quantitative Buffy Coat (QBC) – as possible replacements
for the time-consuming microscopy in the diagnosis of malaria.
Two more rapid assessment techniques (the Optimal 1 and
SD-BIOLINE) were recently introduced into Nigeria and claimed to
exhibit high sensitivity and specificity. Optimal 1 was
particularly claimed to distinguish between P falciparum, P.
malariae, P ovale and P. vivax. We have in this work
evaluated the efficacy of both the Optimal 1 and SD-Bioline in
240 patients from Ibafo and Magboro Communities in Obafemi-Owode
LGA of Ogun State, Nigeria. Results showed that with regard to
the detection of P. falciparum, Optimal 1 gave a
sensitivity, specificity, positive |